European journal of clinical investigation
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Eur. J. Clin. Invest. · Sep 2013
ReviewPathophysiological role of the renin-angiotensin system on erectile dysfunction.
The renin-angiotensin system (RAS) has been shown to play an active role within the erectile tissues. The aim of this narrative review is to summarize the literature addressing the pathophysiological role of RAS on erectile function. Additionally, we update evidence on recent findings on the role of the Ang-(1-7) and Mas receptor on the erectile function and its therapeutic potential for treating erectile dysfunction (ED). ⋯ Ang-(1-7) and Mas receptor pathway might be considered as a promising therapeutic target for the treatment of ED.