European journal of clinical investigation
-
Eur. J. Clin. Invest. · Dec 2020
Review Meta AnalysisEffects of Exercise Programs on Pain, Disease Activity and Function in Ankylosing Spondylitis: A Meta-Analysis of Randomzied Controlled Trials.
To evaluate the effects of exercise programmes on pain, function and disease activity in patients with ankylosing spondylitis (AS). ⋯ For patients with AS, exercise programmes improve pain, function and disease activity. To confirm the results, more well-designed randomized controlled trials with large number of patients are required.
-
Eur. J. Clin. Invest. · Dec 2020
ReviewRheumatic Heart Disease anno 2020: Impacts of gender and migration on epidemiology and management.
The epidemiology and management of diseases can be influenced by social demographic factors. Gender and migration are among these factors. ⋯ There are contradicting results for outcomes after PBMV between males and females. It is not clear whether sex difference plays a role in pathophysiology, diagnosis, management and prognosis of MS. Migration has impacts on epidemiology and management of RHD. Further studies are required in these two fields to explore their relationship to RHD.
-
Epigenetic events involving the methylation of CpG cites in DNA, histone modifications and noncoding RNAs correlated with many essential processes in human cells and diseases, such as cancer and cardiovascular diseases. HMG-CoA reductase inhibitors (statins)-the LDL cholesterol-lowering drugs-are broadly used in cardio- and cerebro-vascular diseases. It is well established that statins exert pleiotropic functions, but how they exert effects on epigenetic modifications independently of HMG-CoA reductase inhibition is not yet clear. Thereby, understanding these mechanisms may pave the way for further clinical application of statin therapy. ⋯ This review suggests that the epigenetic effects of statins mediate, at least in part, the pleiotropic actions of these drugs but further validation of such effects in clinical studies is yet to be provided.