European journal of clinical investigation
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Eur. J. Clin. Invest. · Nov 2021
Meta AnalysisConvalescent Plasma for COVID-19: A Meta-analysis of Clinical Trials and Real-World Evidence.
There is still a lack of consensus on the efficacy of convalescent plasma (CP) treatment in COVID-19 patients. We performed a systematic review and meta-analysis to investigate the efficacy of CP vs standard treatment/non-CP on clinical outcomes in COVID-19 patients. ⋯ Convalescent plasma use was associated with reduced risk of all-cause mortality in severe or critical COVID-19 patients. However, the findings were limited with a moderate degree of heterogeneity. Further studies with well-designed and larger sample size are needed.