European journal of clinical investigation
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Eur. J. Clin. Invest. · Jun 2021
Review Meta AnalysisEffects of hypertension on cancer survival: A meta-analysis.
Hypertension is usually associated with increased cardiovascular mortality. Uncertainty exists about the possible role of hypertension as a poor prognostic factor for cancer-specific mortality (CSM). To assess the association between pre-existing hypertension and the risk of mortality and relapse after a diagnosis of cancer, we performed a systematic review and meta-analysis of published studies. ⋯ Among cancer patients, those with pre-existing hypertension have a poorer outcome, probably due to multifactorial reasons. Adequate control of lifestyle, more intensive follow-ups, monitoring for hypertension- and anticancer-related cardiovascular complications, and establishing multidisciplinary cardio-oncology units can be useful measures for reducing mortality and improving care in this setting.
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Eur. J. Clin. Invest. · Jun 2021
Meta AnalysisBMI and Atrial Fibrillation Recurrence Post Catheter Ablation: A Dose-Response Meta-analysis.
The evidence on the association between obesity and atrial fibrillation (AF) recurrence was equivocal. We aimed to evaluate the dose-response relationship between body mass index (BMI) and AF recurrence and adverse events. ⋯ CRD42020198787.
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Eur. J. Clin. Invest. · Jun 2021
ReviewProcedure-related bleeding risk in patients with cirrhosis and severe thrombocytopenia.
Gaps of knowledge still exist about the potential association between severe thrombocytopenia and increased risk of procedure-associated bleeding in patients with liver disease. ⋯ Currently available literature cannot support definitive conclusions about the appropriate target platelet counts to improve the risk of bleeding in cirrhotic patients who underwent invasive procedures; moreover, it showed enormous variability in the use of prophylactic platelet transfusions.
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Eur. J. Clin. Invest. · Jun 2021
Effects of age and comorbidities on serum levels of inflammatory markers in community-acquired pneumonia.
Studies have suggested that an inappropriate inflammatory response is a major cause of treatment failure and mortality in patients with community-acquired pneumonia (CAP). We aimed to determine the effect of age and comorbidities on serum inflammatory markers in CAP. ⋯ The circulating inflammatory markers to CAP have profiles that differ with age and underlying comorbidities. Multimorbidity in the elderly is also associated with lower serum levels of some inflammatory markers. Our findings suggest that inflammatory markers in CAP should be interpreted after considering age and comorbid conditions.