European journal of clinical investigation
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Eur. J. Clin. Invest. · Jul 2021
Review Meta AnalysisCirculating serum and plasma levels of micro-RNA in type-1 diabetes in children and adolescents: a systematic review and meta-analysis.
Type 1 diabetes mellitus (T1DM) is a complex metabolic disorder characterized by hyperglycaemia, with constantly increasing incidence in paediatric population. The discovery of new molecules, such as microRNAs, and their possible interactions with T1DM create novel aspects in the diagnosis of the disease. ⋯ A total of three micro-RNA molecules appeared to have a significantly different expression in T1DM patients, serving as a possible diagnostic panel of biomarkers. These findings may contribute as reference for future research to further support the use of microRNAs as a novel diagnostic tool in T1DM.