European journal of clinical investigation
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Eur. J. Clin. Invest. · Dec 2022
Sex steroids and sex steroid-binding globulin levels among middle-aged and elderly men and women from general population.
Availability of age- and sex-specific reference values for sex steroids and sex steroid-binding globulin (SHBG) levels allows for appropriate interpretation of research findings and their clinical applications. We report the sex-specific distribution and reference levels of sex steroids, including total estradiol, total testosterone and (calculated) free androgen index (cFAI), SHBG and other androgens dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS) and androstenedione across age. ⋯ Our study underlines sex-specific trends in sex steroids and SHBG levels with ageing. This warrants taking into account sex- and age-specific reference values for sex steroids and SHBG when investigating their impact on health outcomes to prevent controversial results and allow for their appropriate clinical application.
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Eur. J. Clin. Invest. · Dec 2022
Review Meta AnalysisIncidence of immune checkpoint inhibitor mediated cardiovascular toxicity: A systematic review and meta-analysis.
Immune checkpoint inhibitors (ICI) are a novel class of anti-cancer therapy becoming increasingly associated with fatal cardiovascular toxicities (CVTs). The aim is to determine the incidence of CVTs in cohorts treated with ICIs as sole anti-cancer therapy. ⋯ ICI-mediated CVTs are rare and potentially fatal. The role of CV risk factors in their development remains unclear.
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Eur. J. Clin. Invest. · Dec 2022
Meta AnalysisPrognostic value of soluble urokinase-type plasminogen activator receptor in coronary artery disease: A meta-analysis.
A potential inflammatory biomarker, soluble urokinase-type plasminogen activator receptor (suPAR) has been utilized to assist the prognostic assessment of coronary artery disease (CAD) patients; however, outcomes have been inconsistent. The prognostic relevance of suPAR as a predictor of CAD patient adverse outcomes was therefore examined. ⋯ In patients with coronary disease, suPAR may have prognostic value for both all-cause and cardiovascular mortality but not for other major cardiovascular events.
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Eur. J. Clin. Invest. · Dec 2022
Meta AnalysisCirculation tumor DNA in predicting recurrence and prognosis in operable colorectal cancer patients: a meta-analysis.
Selecting the appropriate patient for further treatment after surgery and adjuvant chemotherapy (ACT) for colorectal cancer (CRC) can improve the patient's prognosis. Circulating tumour DNA (ctDNA) has the potential to predict recurrence and prognosis after CRC surgery and ACT, but the results are still inconclusive. ⋯ ctDNA-positive patients were at a high risk of recurrence after CRC surgery and ACT and had a poorer prognosis. Hence, ctDNA-positive patients required close follow-up and further treatments.