European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2023
Early pregnancy triglycerides and not fructosamine are associated with birth weight (with foetal sexual dimorphism).
We evaluated whether maternal triglycerides (TGs) or fructosamine (measured in early pregnancy) predominantly contribute to birth weight (BW), in a foetal sexual dimorphism. ⋯ Maternal TGs were more dominant (compared to fructosamine) in its association with BW (measured in early physiological pregnancy) and more prominently present when carrying a male foetus. These remarkable observations warrant more future research, especially in obese patients at risk for gestational diabetes.
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Eur. J. Clin. Invest. · Jan 2023
ReviewBig Data and Machine Learning to tackle Diabetes Management.
Type 2 Diabetes (T2D) diagnosis is based solely on glycaemia, even though it is an endpoint of numerous dysmetabolic pathways. Type 2 Diabetes complexity is challenging in a real-world scenario; thus, dissecting T2D heterogeneity is a priority. Cluster analysis, which identifies natural clusters within multidimensional data based on similarity measures, poses a promising tool to unravel Diabetes complexity. ⋯ Fully profiling the individuals, considering genomic and environmental factors, and exposure time, will allow the drive to precision medicine and prevention of complications.
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Eur. J. Clin. Invest. · Jan 2023
The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma.
To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. ⋯ Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.
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Eur. J. Clin. Invest. · Jan 2023
Review Meta AnalysisAngiotensin Converting Enzyme 2 level and its significance in COVID19 and other diseases patients.
Angiotensin-converting enzyme 2 (ACE2) expressions and its modulation are of great interest as being a key receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and the protective arm of the rennin-angiotensin axis, maintaining cardiovascular homeostasis. However, ACE2 expressions and their modulation in the healthy and disease background are yet to be explored. ⋯ It was observed that utilizing the ACE2 by SARS-CoV2 for its entry and its consequence leads to several complications. So there is a need to investigate the underlying mechanism along with novel therapeutic strategies.
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Eur. J. Clin. Invest. · Jan 2023
Meta AnalysisThe Risk for Chronic Kidney Disease in Metabolically Healthy Obese Patients: A Systematic Review and Meta-Analysis.
Chronic kidney disease (CKD) is associated with obesity and metabolic syndrome. Nevertheless, the association of CKD with phenotype referred as metabolically healthy obese or overweight is unclear. In this this systematic review and meta-analysis, we investigate the relationships between obesity and CKD independent of metabolic syndrome by appraising published evidence in studies focusing on metabolically healthy obese people. ⋯ Metabolically healthy overweight and obese individuals have higher risk of CKD compared to individuals without weight excess.