European journal of clinical investigation
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Eur. J. Clin. Invest. · Jun 2023
Insight into the causality between basal metabolic rate and endometrial and ovarian cancers: analysis utilizing systematic Mendelian randomization and genetic association data from over 331,000 UK Biobank participants.
Observational studies have demonstrated that basal metabolic rate (BMR) is associated with the risk of endometrial cancer (EC) and ovarian cancer (OC). However, it is unclear whether these associations reflect a causal relationship. ⋯ The MR study provided etiological evidence for the positive association of BMR with the risk of EC, EEC, OC, CCOC and EOC. But this study did not provide enough evidence suggesting the causal associations of BMR with IMOC, HGSOC and LGSOC.
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Eur. J. Clin. Invest. · Jun 2023
Medication Non-adherence Patterns and Profiles for Patients with Incident Myocardial Infarction: Observations from a Large Multi-morbid US Population.
Consistent adherence levels to multiple long-term medications for patients with cardiovascular conditions are typically advocated in the range of 50% or higher, although very likely to be much lower in some populations. We investigated this issue in a large cohort covering a broad age and geographical spectrum, with a wide range of socio-economic disability status. ⋯ We found consistent patterns of intermediate non-adherence for each of four drug classes for MI cohorts in the order of 56% who are eligible for interventions aimed at improving cardiovascular medication adherence levels. These insights may help improve cardiovascular medication adherence using large medication non-adherence improvement programs.
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Eur. J. Clin. Invest. · Jun 2023
Estimated glomerular filtration rate, haemodynamics, and mortality in patients with aortic stenosis.
In aortic stenosis (AS), estimated glomerular filtration rate (eGFR) is an important prognostic marker but its haemodynamic determinants are unknown. We investigated the correlation between eGFR and invasive haemodynamics and long-term mortality in AS patients undergoing aortic valve replacement (AVR). ⋯ In patients with AS, low eGFR is a marker of an unfavourable haemodynamic constellation as well as important co-morbidities. This may in part explain the association between low eGFR and increased post-AVR mortality.