European journal of clinical investigation
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Eur. J. Clin. Invest. · Jan 2024
Meta AnalysisThe relationship between sex hormone-binding protein and non-alcoholic fatty liver disease using Mendelian randomisation.
The incidence of non-alcohol fatty liver disease (NAFLD) has been increasing annually with the improvement of living standards. Numerous epidemiological observations have linked sex hormone-binding protein (SHBG) levels to NAFLD. However, evidence of the causal role of SHBG in the development and progression of NAFLD is still absent. Therefore, a systematic assessment of the causal relationship is needed. ⋯ The genetic tendency to high levels of SHBG was causally correlated with a reduced risk of NAFLD, indicating that circulating high levels of SHBG was a protective factor for NAFLD.