European journal of clinical investigation
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Eur. J. Clin. Invest. · May 2024
Randomized Controlled TrialEducational status affects prognosis of patients with heart failure with reduced ejection fraction: A post-hoc analysis from the WARCEF trial.
The influence of social determinants of health (SDOH) on the prognosis of Heart Failure and reduced Ejection Fraction (HFrEF) is increasingly reported. We aim to evaluate the contribution of educational status on outcomes in patients with HFrEF. ⋯ NCT00041938.
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Eur. J. Clin. Invest. · May 2024
Effect of statins on sepsis and inflammatory factors: A Mendelian randomization study.
As inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins can reduce the synthesis of low-density lipoptrotein cholesterol (LDL-C), and are clinically used as first-line lipid-lowering drugs to prevent cardiovascular diseases. However, the effect of statins on sepsis is controversial. Therefore, we intend to explore the effects of statins on sepsis and inflammatory factors through Mendelian randomization (MR). ⋯ Statins may have a protective effect on sepsis and this may provide a new idea for the treatment of sepsis.
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Eur. J. Clin. Invest. · May 2024
The association between atrial fibrillation and dementia: A UK linked electronic health records cohort study.
We investigated the association between atrial fibrillation (AF) and dementia, and its subtypes (vascular-VaD, Alzheimer, mixed and rare dementia), and identified predictors for dementia in AF patients. ⋯ AF patients have an increased risk of dementia, independent of stroke, with highest risk of VaD. Management and prevention of the identified risk factors could be crucial to reduce the increasing burden of dementia.