Lancet
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Comparative Study
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance.
A receptor for leptin has been cloned from the choroid plexus, the site of cerebrospinal-fluid (CSF) production and the location of the blood/cerebrospinal-fluid barrier. Thus, this receptor might serve as a transporter for leptin. We have studied leptin concentrations in serum and (CSF). ⋯ Our data suggest that leptin enters the brain by a saturable transport system. The capacity of leptin transport is lower in obese individuals, and may provide a mechanism for leptin resistance.
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Retraction Of Publication
Retraction: familial Alzheimer's disease associated with S182 codon 286 mutation.