Lancet
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Letter Clinical Trial Controlled Clinical Trial
Effect of sleep deprivation on surgeons' dexterity on laparoscopy simulator.
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Case Reports
Seven deaths in Darwin: case studies under the Rights of the Terminally Ill Act, Northern Territory, Australia.
During the 9 months between July, 1996, and March, 1997, the provision of euthanasia for the terminally ill was legal in the Northern Territory of Australia. Seven patients made formal use of the Rights of the Terminally Ill (ROTI) Act; four died under the Act. We report their clinical details and the decision-making process required by the Act. ⋯ Provision of opinions about the terminal nature of illness and the mental health of the patient, as required by the ROTI Act, created problematic gatekeeping roles for the doctors involved.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised trial of albendazole and pyrantel in symptomless trichuriasis in children.
We aimed to find out whether symptomless infection with Trichuris trichiura is associated with impairment of growth and to assess the effect of a multiple-doses regimen of anthelmintic drugs on the growth of children. ⋯ Symptomless trichuriasis impairs growth and albendazole or pyrantel may affect growth, independently of a therapeutic action on parasites. Possible toxic effects of high-dose albendazole require further investigation.
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A specific inherited muscle membrane disorder predisposes to a variety of clinical problems. The most common is malignant hyperthermia (MH), a dangerous hypermetabolic state after anaesthesia with suxamethonium and/or volatile halogenated anaesthetic agents. MH may also be triggered in susceptible individuals by severe exercise in hot conditions, infections, neuroleptic drugs, and overheating in infants. ⋯ In pigs susceptibility to MH is caused by a single mutation in the ryanodine receptor (RYR) in skeletal muscle. In man the genetics is more complex and three clinical myopathies that predispose to MH have been defined. By far the most common is inherited as a mendelian dominant characteristic and at present mutations in the human RYR account for no more than 20% of susceptible families.
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Letter Randomized Controlled Trial Clinical Trial
Randomised study of skin-to-skin versus incubator care for rewarming low-risk hypothermic neonates.