Lancet
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Rhythm or rate control in atrial fibrillation--Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial.
Atrial fibrillation is the most commonly encountered sustained cardiac arrhythmia. Restoration and maintenance of sinus rhythm is believed by many physicians to be superior to rate control only. However, there are no prospective data that compare both therapeutic strategies. ⋯ With respect to symptomatic improvement in patients with atrial fibrillation, the therapeutic strategies of rate versus rhythm control yielded similar clinical results overall. However, exercise tolerance is better with rhythm control, although hospital admission is more frequent. These data may serve as a basis to select therapy in individual patients.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial.
Warfarin-associated coagulopathy is a frequent clinical complication. We aimed to assess whether treatment with vitamin K is safe and more effective than placebo in rapidly lowering the international normalised ratio (INR) into the therapeutic range in over anticoagulated patients receiving warfarin. ⋯ Low dose oral vitamin K is more effective than placebo for the rapid lowering of raised INR values in patients taking warfarin.