Lancet
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Randomized Controlled Trial Multicenter Study
General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial.
The effect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is offset by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia. ⋯ The Health Foundation (UK) and European Society of Vascular Surgery.
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Biography Historical Article
Martin Birchall: using stem cells to help make transplant history.
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Randomized Controlled Trial Multicenter Study Comparative Study
Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial.
Calcitonin gene-related peptide (CGRP) probably has a role in migraine pathophysiology, and antagonism of its receptors might provide treatment without the vasoconstrictor effects of triptans. We aimed to assess the clinical profile of MK-0974 (telcagepant), an orally bioavailable antagonist of CGRP receptor. ⋯ Merck Research Laboratories.