Lancet
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Randomized Controlled Trial Multicenter Study Comparative Study
Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial.
Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise high-density lipoprotein cholesterol (HDL-C). After the failure of torcetrapib it was unknown if HDL produced by interaction with CETP had pro-atherogenic or pro-inflammatory properties. dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints. ⋯ F Hoffmann-La Roche Ltd.
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Randomized Controlled Trial Comparative Study
Comparison of stratified primary care management for low back pain with current best practice (STarT Back): a randomised controlled trial.
Back pain remains a challenge for primary care internationally. One model that has not been tested is stratification of the management according to the patient's prognosis (low, medium, or high risk). We compared the clinical effectiveness and cost-effectiveness of stratified primary care (intervention) with non-stratified current best practice (control). ⋯ Arthritis Research UK.
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Randomized Controlled Trial Multicenter Study
Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial.
The increasing prevalence of overweight and obesity needs effective approaches for weight loss in primary care and community settings. We compared weight loss with standard treatment in primary care with that achieved after referral by the primary care team to a commercial provider in the community. ⋯ Weight Watchers International, through a grant to the UK Medical Research Council.
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Randomized Controlled Trial Comparative Study
Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery (PEACOG): a randomised controlled trial.
For some surgical procedures to be done, a patient's blood circulation needs to be stopped. In such situations, the maintenance of blood flow to the brain is perceived beneficial even in the presence of deep hypothermia. We aimed to assess the benefits of the maintenance of antegrade cerebral perfusion (ACP) compared with deep hypothermic circulatory arrest (DHCA). ⋯ J P Moulton Charitable Foundation.