Medicine
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Psoriasis vulgaris is complicated with metabolic syndrome and other diseases, which affects the longevity of patients. Its repeated attacks bring obvious and long-term treatment burden to patients, and improper self-management can aggravate disease symptoms and increase the risk of complications. To summarize the existing evidence on the self-management of psoriasis vulgaris treatment burden. ⋯ Finally, we present 34 items of best evidence. This study provides the basis for the management of treatment burden of psoriasis vulgaris. According to this study, medical workers guide patient to reduce the disease and treatment burden.
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Meta Analysis
The association between circulating Hcy and Lp-PLA2 levels and poststroke depression: A meta-analysis.
To analyze the correlation between circulating homocysteine (Hcy) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and poststroke depression (PSD). ⋯ Circulating Hcy and Lp-PLA2 levels are linked to the development of PSD, and can be applied as predictive or diagnostic indicators.
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Meta Analysis
Comparison of UPDRS III score between young and late onset Parkinson disease after deep brain stimulation: A meta-analysis.
Parkinson disease (PD) is a common age-related neurodegenerative disease. Subthalamic nucleus deep brain stimulation (DBS) is a safe and effective surgical treatment for medically resistant advanced PD. However, the relationship between the age at PD onset and the efficacy of subthalamic nucleus DBS surgery remains unclear. Thus, we conducted a meta-analysis to compare motor symptom improvements after DBS for the treatment of young-onset and late-onset PD. ⋯ The efficacy of DBS in patients with YOPD and LOPD showed similar improvements in the UPDRS score; hence, DBS should be considered, if necessary, regardless of the onset age of PD.
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Depression, a prevalent psychiatric malady, afflicts a substantial global demographic, engendering considerable disease burden due to its elevated morbidity and mortality rates. Contemporary therapeutic approaches for depression encompass the administration of serotonin reuptake inhibitors, monoamine oxidase inhibitors, and tricyclic antidepressants, albeit these pharmaceuticals potentially induce adverse neurological and gastrointestinal effects. ⋯ Additionally, we deliberated the antidepressant mechanisms of natural medicines comprising alkaloids, flavonoids, polyphenols, saponins, and quinones via diverse pathways. This research endeavor endeavored to encapsulate and synthesize the progression of TCMs in modulating HPA axis-associated signaling pathways to mitigate depression, thereby furnishing robust evidence for ensuing research in this domain.
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Review Case Reports
A neonatal case report of branchiooculofacial syndrome caused by a novel mutation in the TFAP2A gene and literature review.
Branchiooculofacial syndrome (BOFS) is a rare autosomal dominant disorder with a diverse clinical phenotype. To summarise the clinical characteristics and genetic variations of neonatal-onset BOFS through a case study and literature review. ⋯ The characteristic facial features, branchial skin defects, and ocular anomalies are the main clinical manifestations of BOFS with neonatal onset, but the diverse clinical phenotype and variable genetic variants pose certain challenges for clinical diagnosis.