Medicine
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Meta Analysis
Short-term effects of denervation in the treatment of hypertension: A meta-analysis excluding drug interferences.
To evaluate the short-term efficacy of denervation in treating hypertension with the exclusion of drug-interfering factors. ⋯ Denervation has the potential to reduce blood pressure in the short-term for patients with medication-naïve hypertension, demonstrating an acceptable safety profile. This offers hope for patients who are intolerant to drug therapy or unwilling to take lifelong medication. However, its long-term effects require further study. Future research should focus on expanding the sample size and prolonging the follow-up period to further solidify its role in the treatment of hypertension.
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Observational Study
Development and performance evaluation of a clinical prediction model for sepsis risk in burn patients.
Sepsis is a common and severe complication in burn patients and remains one of the leading causes of mortality. This retrospective study aimed to develop a predictive model for the risk of in-hospital sepsis among burn patients treated at Guangzhou Red Cross Hospital between January 2022 and January 2024, with the goal of improving clinical outcomes through early prevention based on risk stratification. A total of 302 eligible patients were randomly divided into training and validation cohorts in a 7:3 ratio for model development and validation, respectively. ⋯ The areas under the receiver operating characteristic curve were 0.875 and 0.861 for the training and validation cohorts, with Youden indexes of 0.634 and 0.600, respectively. The calibration curve and decision curve analysis demonstrated good predictive accuracy and clinical utility of the model. These findings suggest that our developed model exhibits robust predictive performance for the risk of in-hospital sepsis in burn patients, and early prevention strategies based on risk stratification may potentially improve clinical outcomes.
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Observational Study
The correlation between driving risk and visual attention when using smartphones while driving in novice drivers.
Although many countries restrict the use of smartphones while driving, smartphones are utilized in various ways as there are limits to enforcement. Accordingly, efforts are made to determine the risks of novice drivers with low safety awareness and higher risk. This study observed and analyzed changes in visual attention and driving risks according to the way smartphones are used while driving and the scientific relationship between the 2 variables. ⋯ When novice drivers use smartphones while driving compared to when they do not use smartphones, changes in visual attention characteristics in the number and duration of eye blinks, eye fixations, and saccades increased the risk of accidents due to deceleration and lane departure. In particular, the risk increased the most when sending messages, and the risk of accidents continued although the increased burden due to smartphone use was compensated for by slowing down the speed. We hope that the findings of this study will be actively used in efforts to change novice drivers' traffic safety attitudes while driving.
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This study aimed to assess the impact of the timing of low-dose hydrocortisone adjuvant therapy initiation on clinical outcomes in patients with septic shock by a systematic review and meta-analysis. ⋯ Administering low doses of HC early on can decrease the risk of death in septic shock patients in the short-term mortality. There were no substantial disparities observed in the rate of CRRT, the rate of reversal of shock, and the duration of stay in the ICU. Additional extensive RCTs are required to validate this conclusion.
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To comprehensively review cardiorenal syndrome (CRS)-related research, this study analyzes its whole landscape and future trends from a bibliometric perspective. Using "cardiorenal syndrome" as the key word, a representative dataset of CRS was constructed in the Web of Science Core Collection (Science Citation Index Expanded) database up to November 2023. VOSviewer (version 1.6.18) and R-Studio (version 1.4) were used to visualize CRS-related author and national collaboration networks, hotspot distribution clustering and historical citation networks. ⋯ Combined with keyword co-occurrence, theme evolution, and strategic distribution analysis, it was found that centering on the mechanism of CRS (cardiovascular lesions, venous congestion, and fibrosis), prognosis (transplantation, dialysis, hospitalization, mortality) and cardiac function management (b-type natriuretic peptide, diastolic dysfunction, left ventricular hypertrophy) is a possible research direction for a long time to come. Although CRS has a relatively short history, it has received a lot of attention and is currently enjoying a high level of overall acceptance. In conclusion, this study explores the major research areas, frontiers and trends in CRS, which are important for future research.