Medicine
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Folate is a vitamin that is exclusively derived from diet sources. Low folate levels are typically associated with cardiovascular disease, cognitive impairment, and cancer risk. However, few studies have examined the direct relationship between serum folate levels and sleep duration. ⋯ In the threshold analysis, for participants with serum folate of <32.208 nmol/L (β = 0.608, 95% CI: (0.275, 0.942), P < .001), the sleep duration was significantly increased by 0.608 minutes, with every 1 nmol/L in serum folate increased. At serum folate of ≥32.208 nmol/L, no significant association between serum folate and sleep duration was detected [β = 5.686, 95% CI: (-1.508, 12.88), P = .118]. Our findings revealed an inverted L-shaped relationship and saturation effects between serum folate levels and sleep duration in adults in the United States.
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While observational studies have illustrated correlations between plasma metabolites and gastric cancer (GC), the causal association between the 2 is still unclear. Our study aims to delineate the bidirectional relationship between plasma metabolites and GC and find potential metabolic pathways. We undertook a bidirectional 2-sample Mendelian randomization (MR) analysis to investigate the causal relationship, specificity, and direction of association between 1400 plasma metabolites and GC. ⋯ Furthermore, our analysis identified 18 significant metabolic pathways, including Arginine and proline metabolism (P < .009) and Valine, leucine, and isoleucine biosynthesis (P < .031). Our findings offer evidence supporting potential casual relations between multiple plasma metabolites and GC. These findings may offer great potential for future application of these biomarkers in GC screening and clinical prevention strategies.
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Previous research has shown that internal signals from the body can modulate the processing of external stimuli. This study investigated whether respiratory phases influence auditory deviance detection by recording mismatch negativity (MMN) responses of event-related brain potentials. ⋯ This study provides further evidence that respiratory phases influence the auditory processing of external events.
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Observational Study
Association between severity of pancreatic exocrine insufficiency and computed tomography-based morphological severity in patients with chronic pancreatitis.
The association between pancreatic exocrine insufficiency (PEI) and morphologic findings in chronic pancreatitis has not yet been fully studied. Thus, the aim of this study was to investigate the correlation between PEI severity and computed tomography (CT)-based morphological severity in patients with chronic pancreatitis. This nationwide survey included 180 Korean participants with chronic pancreatitis aged 18 years or older between January 2018 and December 2021. ⋯ PEI severity showed a significant improvement after PERT (P < .001). In conclusion, PEI severity had significant associations with CT-based morphological severities, including severities of pancreatic duct caliber and pancreatic duct stricture or intraductal obstructing calculus. In addition, PEI-Q could be a useful indicator for evaluating the therapeutic effect of PERT in clinical practice.
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Observational Study
Assessment of frontal QRS-T angle in distinguishing mild and severe acute pancreatitis in emergency department: A retrospective study.
Acute pancreatitis (AP) is a disease that poses significant health risks with potential severe outcomes. Identifying markers for severity can aid in early intervention and improve prognoses. This study, conducted in the emergency department, investigates the QRS-T angle as a potential indicator of severity in patients with acute pancreatitis. ⋯ Additionally, severe pancreatitis group showed higher QRS-T angle (P < .001), higher rates of abnormal QRS angles (31.8% vs 10.1%, P = .002), and QRS-T angles (31.8% vs 8.1%, P < .001). The QRS-T angle may serve as a valuable clinical tool for differentiating between mild and severe forms of acute pancreatitis. This could potentially help clinicians in stratifying patients according to their risk and tailoring their management accordingly.