Medicine
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Extramedullary plasmacytoma is an extremely rare malignant clonal plasmacytoma, which can occur in any tissue or organ of the body other than bone marrow hematopoietic tissue. Lesions mostly occur in the head and neck or upper respiratory tract, and rarely in the lower respiratory tract. Primary plasmacytoma of the lung, also known as primary pulmonary plasmacytoma (PPP), is rarer and is mainly diagnosed on the basis of the histopathology of biopsy tissue. In this report, we present a case of PPP. ⋯ PPP is a rare lung tumor, and diagnosis of this lesion on the basis of bronchoscopic biopsy is even rarer. With this case report, we seek to enhance the awareness and understanding of PPP. We recommend that in cases wherein chest imaging findings suggest multiple lung lesions, the possibility of pulmonary plasmacytoma should also be considered, and biopsy should be actively performed to confirm the diagnosis and guide treatment. This report provides valuable insights and guidance for clinicians in the management and diagnosis of patients with PPP.
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Takayasu arteritis (TAK) is an autoimmune disease that causes chronic inflammation targeting the aortic wall. Since many patients are resistant to steroid treatment, multiple immunosuppressants or interleukin-6 (IL-6) suppression therapy have served as treatment alternatives. However, there are very few reports on the effectiveness of biologics against inflammatory cytokines upstream of IL-6. ⋯ Since IL-17 is an important cytokine in the pathogenesis of TAK, anti-cytokine therapy targeting IL-17 may be effective for TAK.
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Effective analgesia and sedation management play a crucial role in reducing the intensity of coughing in patients with endotracheal intubation and improving clinical outcomes. However, current approaches are predominantly singular and lack comprehensive management strategies based on multidisciplinary collaboration. This study aims to evaluate the impact of multidisciplinary collaborative bundled care on analgesia and sedation in intensive care unit (ICU) patients with endotracheal intubation, providing evidence to inform clinical practice. ⋯ Multidisciplinary collaborative bundled care improves sedation and analgesia outcomes in ICU patients with endotracheal intubation, reducing medication dosage, incidence of delirium, physical restraint use, and duration of mechanical ventilation while enhancing cough strength.
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More and more studies have shown that Chinese medicine can effectively and safely treat allergic rhinitis (AR) in children. This meta-analysis aims to compare the efficacy and safety differences between conventional therapy and the Chinese herbal medicine Cang-Er-Zi-San (CEZS) from an evidence-based perspective, and guide the clinical treatment of pediatric AR. ⋯ CEZS has a definite therapeutic effect on children with AR and is an effective method for treating it. However, due to biased results and limited research, a large number of high-quality studies are needed to validate the effectiveness of CEZS and provide new treatments for clinical reference.
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Review Case Reports
Leptospirosis manifested with severe pulmonary hemorrhagic syndrome successfully treated with veno-venous extracorporeal membrane oxygenation: A case report and literature review.
The mortality rate associated with pulmonary hemorrhage induced by leptospirosis is notably high. Available treatment modalities are limited, and their efficacy has not been fully demonstrated. Here, we present the case report of a patient with leptospirosis-induced pulmonary hemorrhagic syndrome. A 49-year-old male patient was admitted to the Surgical Ward of the Department of Intensive Care Medicine of Fuyang Infectious Disease Clinical College of Anhui Medical University. The patient had initially sought medical attention at a local hospital due to symptoms of fever persisting for 4 days and chest tightness accompanied by hemoptysis for 1 day. ⋯ We successfully treated a case of leptospirosis pulmonary hemorrhagic syndrome using VV-ECMO combined with prudent anticoagulant therapy.