Medicine
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The objective of this study is to examine the impact of intellectual capital (IC) and its elements on private hospital performance. In addition, this study explores the moderating role of digital transformation in the relationship between IC and its elements and private hospital performance. This study selects 13 private listed hospitals from 2012 to 2022 as the sample. ⋯ The results show that IC and only one element (structural capital) have a positive impact on private hospital performance, while human and relational capitals have no significant impact. Surprisingly, digital transformation negatively moderates the relationship between IC and private hospital performance. This study underscores the pivotal role of IC in enhancing the performance of private hospitals, and hospital managers should accelerate hospital digital transformation in the digital era.
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Mugua is a Chinese herbal medicine derived from the dried mature fruit of Chaenomeles speciosa (Sweet) Nakai. This study aimed to dissect the active ingredients and mechanism of Mugua. In the present study, the active components of Mugua were collected and screened through databases combined with UPLC-Q/TOF-MS based qualitative analysis and literature mining, and their potential disease targets were predicted. ⋯ These results suggested that Mugua could exert traditional efficacy through multi-component and multi-target synergistic mechanisms. Molecular docking results showed that all key active ingredients could autonomously bind to the shared core targets, and the in vitro anti-inflammatory results further confirmed that all the key active components had good anti-inflammatory activities. The present study found that Mugua mainly intervened in the inflammatory response and pathways by acting on key active components and core targets to exert traditional efficacy, providing a theoretical basis for further in-depth research.
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This study investigated the potential association between uranium exposure and mortality from cerebrovascular diseases, with a focus on the mediating effects of lipid indicators. Employing recommended sampling weights to account for National Health and Nutrition Examination Survey' complex survey design, this analysis drew from data collected between 2005 and 2016. The study examined the impact of uranium on mortality from cerebrovascular diseases using various statistical approaches, including Cox regression to assess linear relationships within metal mixtures. ⋯ The study encompassed 4312 participants and established a significant direct link between uranium levels and mortality from cerebrovascular diseases (hazard ratio (95%CI) = 20.4243 (20.1347-20.7181), P = .0266). It also identified LAP as a mediating factor in the relationship, accounting for a mediated proportion of 1.35%. The findings highlight a pivotal connection between uranium exposure and increased mortality due to cerebrovascular diseases, with LAP playing a significant intermediary role.
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This article provides a comprehensive review of recent research advancements in sacroiliac joint reduction therapy for addressing lumbosacral pain and gait balance issues, delving into its application efficacy, future outlook, and existing challenges. Current literatures were searched on sacroiliac joint reduction therapy, lumbosacral pain and gait balance disorders using the databases PubMed and Cochrane. There were no restrictions when conducting the literature search with regard to publication date, study language, or study type. ⋯ Future research avenues should prioritize the development of precise diagnostic tools and standardized treatment protocols to enhance the efficacy and safety of sacroiliac joint reduction therapy. Moreover, interdisciplinary collaboration is paramount, leveraging the expertise of physical therapists, rehabilitation specialists, and spine surgeons to offer comprehensive treatment solutions. Sacroiliac joint reduction therapy emerges as a compelling therapeutic option for individuals grappling with lumbosacral pain and gait instability, showcasing significant clinical potential and promising future prospects.
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Pediatric obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder associated with significant neurocognitive and behavioral impairments. Recent studies have highlighted the role of gut microbiota and the microbiota-gut-brain axis (MGBA) in influencing cognitive health in children with OSA. This narrative review aims to summarize current knowledge on the relationship between gut microbiota, MGBA, and cognitive function in pediatric OSA. ⋯ MGBA mechanisms, such as endocrine, immune, and neural pathways, link gut microbiota to cognitive outcomes. Artificial intelligence and machine learning methodologies offer promising tools to uncover microbial markers and mechanisms associated with cognitive deficits in OSA. Future research should focus on validating these findings through clinical trials and developing personalized therapeutic approaches targeting the gut microbiota.