Medicine
-
Rapid diagnosis of acute ischemic stroke (AIS) remains challenging, and reliable biomarkers are needed. MicroRNAs (miRNAs) are endogenous small noncoding regulatory RNA molecules present in the serum, plasma, and saliva. miRNAs are considered to be sensitive biomarkers of tissue damage because of their high stability and relative tissue specificity. The aim of this systematic review was to assess the correlation between miRNAs and infarct volume in patients with AIS, to provide a basis for predicting ischemic stroke onset and improving prognosis in the clinic, among others. ⋯ This study shows that miRNA can be used as a biomarker for AIS, reflecting the severity of neurological deficits in this patient and providing a basis for clinical judgement of the patient's prognosis.
-
The relationship between dietary nutrient intake and bone mineral density (BMD) has not been clarified. In the U. S. population, we have demonstrated that dietary intake of multiple nutrients (potassium, magnesium, and sodium) is positively associated with BMD and negatively associated with the prevalence of osteopenia. ⋯ Our study showed that intake of dietary nutrients (potassium, magnesium, and sodium) was correlated positively to femur BMD and adversely to osteopenia and osteoporosis in the U. S. population. Further research is needed on the association of dietary elemental intake with BMD.
-
Parkinson disease (PD) is a progressive neurological disorder that may be managed with therapies like scalp electroacupuncture (SEA). The combination of SEA and medication could potentially offer a new approach for managing PD symptoms. The systematic review and meta-analysis aimed to assess the combined impact of SEA and medication on PD through a comprehensive analysis of randomized clinical trials, focusing on outcomes like effective rate and various scores (total Unified Parkinson Disease Rating Scale (UPDRS), UPDRS III, and Webster). ⋯ The intervention (SEA + medication) has shown significant effectiveness compared to the control (medication) in terms of the effective rate, total UPDRS, and UPDRS III in PD patients. However, it did not show a significant effect on the Webster score.
-
Meta Analysis
No need for hip precautions after total hip arthroplasty with posterior approach: A systematic review and meta-analysis.
Nowadays, total hip arthroplasty (THA) is one of the most successful procedures in the field of orthopedics and trauma. The posterior approach has historically been associated with a higher rate of hip dislocation. To reduce the rate of hip dislocation in the posterior approach, most orthopedic surgeons would recommend hip precautions (HP) for their patients postoperatively based on previous theories. However, recent randomized controlled trials have shown no significant difference in hip dislocation rates with or without HP, in contrast to previous theories. Based on these, this study conducted a meta-analysis of these randomized controlled trials to try to get qualitative conclusions. ⋯ THA with a posterior approach does not require hip precautions.
-
Meta Analysis
Xuebijing and somatostatin against acute pancreatitis: A systematic review and network pharmacology.
Acute pancreatitis (AP) is a common pancreatic disease. Xuebijing injection (XBJ) combined with somatostatin in the treatment of AP is frequently used in clinical practice. There is, however, a lack of high-quality evidence-based evidence and network pharmacology to regard the therapeutic efficacy and pharmacological mechanisms. ⋯ The effectiveness of combination therapy of XBJ and somatostatin on AP is likely to be better than somatostatin. In addition, XBJ and somatostatin synergistically treated AP through a multi-pathway network.