Medicine
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Observational Study
Risk factors for falls in older adults with type 2 diabetes: A cross-sectional study.
The study was to estimate the prevalence of falls with type 2 diabetes (T2D) and investigate the associated risk factors. The study design employed was cross-sectional. The participants for this study were recruited from a community-based diabetes specialist clinic. ⋯ After adjusting for confounding, showed each additional unit on the depression score increases the fall risk by 11.9% (AOR, 1.19; 95% CI, 1.02-1.38, P = .027). Depression was a significant factor for falls in older adults with T2D. The study highlights the importance of targeted, multifaceted clinical interventions focusing on gender, age, and mental health to effectively reduce fall probability and improve the quality of life for the older adults.
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Rheumatoid arthritis (RA) is a chronic autoimmune disease that significantly impacts the quality of life of affected individuals. Observational data have consistently pointed towards an associative relationship between cathepsins and the development of RA. Nonetheless, the establishment of a definitive causal nexus between members of the cathepsin family and the pathogenesis of RA remains elusive. ⋯ Forward MR analyses substantiated a significant genetic correlation between the genetically predicted levels of Cathepsin B and the predisposition to RA, elevated levels of Cathepsin B exhibit a significant association with an increased risk of RA (OR = 1.0727, 95% CI: 1.0171-1.1314, P = .0098). In the reverse MR and multivariable MR analyses, no significant causal relationship was identified between cathepsins and RA. The findings suggest that Cathepsin B may serve as a biomarker for RA, thereby offering significant implications for the advancement of diagnostic and therapeutic strategies in the management of RA.
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This study employs bibliometric techniques to dynamically represent the research landscape of oral and maxillofacial neuralgia. Its goal is to pinpoint research hotspots and delineate forthcoming trends. A systematic search of the Web of Science Core Collection was performed using targeted keywords to retrieve literature from January 2004 to December 2023. ⋯ The emergence of keywords closely correlates with trigeminal neuralgia. Research frontiers in the field of oral and maxillofacial neuralgia are primarily focused on trigeminal neuralgia, with major therapeutic approaches including gamma knife radiosurgery and percutaneous balloon compression. These areas, along with botulinum toxin, represent current hotpots and are likely to drive the future direction of research in treating oral and maxillofacial neuralgia.
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Observational Study
Predictors of active and recurrent bleeding in upper gastrointestinal angiodysplasia: Results from 10-year esophagogastroduodenoscopy of a tertiary center in Taiwan.
Upper gastrointestinal angiodysplasia (UGIA) is a unique mucosal vascular lesion that causes acute or recurrent gastrointestinal bleeding. Despite the increasing incidence of UGIA, the risk factors for bleeding in this condition remain unclear. We investigated the predictors of active and recurrent bleeding among patients with UGIA. ⋯ Multivariate analysis identified diabetes mellitus (DM), chronic kidney disease (CKD), and lesions in the duodenum as significant risk factors for active bleeding (P = .019; P = .006; P = .004). Our cohort study provided real-world data on the clinical and endoscopic features of UGIA. DM, CKD, and lesions in the duodenum were independent predictors of active bleeding.
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Dilated cardiomyopathy (DCM) is characterized by ventricular dilation and poor systolic function. Approximately half of idiopathic DCM cases are assigned to genetic causes in familial or apparently sporadic cases, and more than 50 genes are reported to cause DCM. However, genetic basis of most DCM patients still keeps unknown and require further study. ⋯ Bioinformatic analysis predicted p. G218R mutation as deleterious and pathogenic damaging in DCM patients. Our results reported a potential pathogenic mutation associated with DCM, which may provide further insight into genetic contributions of LAMA4 gene mutations to DCM phenotypes.