JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Clinical Trial
Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study.
In a 16-week randomized, double-blind, vehicle-controlled study of topical tretinoin in the treatment of photoaging, all patients applied topical tretinoin to one forearm and vehicle cream to the other. Half of the patients received tretinoin to the face, and half received vehicle cream. ⋯ Statistically significant histologic changes were seen in forearm skin treated with tretinoin, but not with vehicle cream. Side effects were limited to irritation of tretinoin-exposed skin.