JAMA : the journal of the American Medical Association
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Meta Analysis
Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis.
Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events. ⋯ Compared with aspirin, oral anticoagulant significantly decreases the risk of all strokes, ischemic strokes, and cardiovascular events for patients with nonvalvular chronic or paroxysmal AF but modestly increases the absolute risk of major bleeding. The balance of benefits and risks varies by patient subgroup.