JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Clinical Trial
Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial.
Supplemental perioperative oxygen has been variously reported to halve or double the risk of surgical wound infection. ⋯ Patients receiving supplemental inspired oxygen had a significant reduction in the risk of wound infection. Supplemental oxygen appears to be an effective intervention to reduce SSI in patients undergoing colon or rectal surgery. Trial Registration ClinicalTrials.gov Identifier: NCT00235456.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial.
Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients. ⋯ Therapy to reduce volume overload during hospitalization for heart failure led to marked improvement in signs and symptoms of elevated filling pressures with or without the PAC. Addition of the PAC to careful clinical assessment increased anticipated adverse events, but did not affect overall mortality and hospitalization. Future trials should test noninvasive assessments with specific treatment strategies that could be used to better tailor therapy for both survival time and survival quality as valued by patients.