JAMA : the journal of the American Medical Association
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Randomized Controlled Trial
Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial.
Treating hypertension decreases mortality and disability from cardiovascular disease, but most hypertension remains inadequately controlled. ⋯ Pharmacist care management delivered through secure patient Web communications improved BP control in patients with hypertension. Trial Registration clinicaltrials.gov Identifier: NCT00158639.
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Comparative Study
Outcomes following coronary stenting in the era of bare-metal vs the era of drug-eluting stents.
Although drug-eluting stents reduce restenosis rates relative to bare-metal stents, concerns have been raised that drug-eluting stents may also be associated with an increased risk of stent thrombosis. Our study focused on the effect of stent type on population-based interventional outcomes. ⋯ The widespread adoption of drug-eluting stents into routine practice was associated with a decline in the need for repeat revascularization procedures and had similar 2-year risks for death or ST-elevation myocardial infarction to bare-metal stents.
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Changes over time in epigenetic marks, which are modifications of DNA such as by DNA methylation, may help explain the late onset of common human diseases. However, changes in methylation or other epigenetic marks over time in a given individual have not yet been investigated. ⋯ These data indicate that methylation changes over time and suggest that methylation maintenance may be under genetic control.