JAMA : the journal of the American Medical Association
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Among adult patients with liver disease, the ability to identify those most likely to have cirrhosis noninvasively is challenging. ⋯ For identifying cirrhosis, the presence of a variety of clinical findings or abnormalities in a combination of simple laboratory tests that reflect the underlying pathophysiology increase its likelihood. To exclude cirrhosis, combinations of normal laboratory findings are most useful.
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Comparative Study
Cost-effectiveness of adult vaccination strategies using pneumococcal conjugate vaccine compared with pneumococcal polysaccharide vaccine.
The cost-effectiveness of 13-valent pneumococcal conjugate vaccine (PCV13) compared with 23-valent pneumococcal polysaccharide vaccine (PPSV23) among US adults is unclear. ⋯ Overall, PCV13 vaccination was favored compared with PPSV23, but the analysis was sensitive to assumptions about PCV13 effectiveness against nonbacteremic pneumococcal pneumonia and the magnitude of potential indirect effects from childhood PCV13 on pneumococcal serotype distribution.
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Meta Analysis
Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents.
Sparse data exist on the combined associations between physical activity and sedentary time with cardiometabolic risk factors in healthy children. ⋯ Higher MVPA time by children and adolescents was associated with better cardiometabolic risk factors regardless of the amount of sedentary time.