JAMA : the journal of the American Medical Association
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Meta Analysis
Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.
The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. ⋯ Among African Americans in these cohorts, the presence of SCT was associated with an increased risk of CKD, decline in eGFR, and albuminuria, compared with noncarriers. These findings suggest that SCT may be associated with the higher risk of kidney disease in African Americans.