JAMA : the journal of the American Medical Association
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The incidence of syphilis in the United States is increasing; it is estimated that more than 55,000 new infections will occur in 2014. Treatment regimens are controversial, especially in specific populations, and assessing treatment response based on serology remains a challenge. ⋯ The mainstay of syphilis treatment is parenteral penicillin G despite the relatively modest clinical trial data that support its use.