JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Multicenter Study
Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial.
The benefits of prophylactic antibiotics for hospitalized patients with severe alcohol-related hepatitis are unclear. ⋯ In patients hospitalized with severe alcohol-related hepatitis, amoxicillin-clavulanate combined with prednisolone did not improve 2-month survival compared with prednisolone alone. These results do not support prophylactic antibiotics to improve survival in patients hospitalized with severe alcohol-related hepatitis.