JAMA : the journal of the American Medical Association
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Latent tuberculosis infection (LTBI) can progress to active tuberculosis disease, causing morbidity and mortality. ⋯ No studies directly evaluated the benefits and harms of screening for LTBI compared with no screening. TST and IGRAs were moderately sensitive and highly specific. Treatment of LTBI with recommended regimens reduced the risk of progression to active tuberculosis. Isoniazid was associated with higher rates of hepatotoxicity than placebo or rifampin.