Clinical neurology and neurosurgery
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Clin Neurol Neurosurg · Dec 2008
Randomized Controlled TrialA double-blind randomized controlled trial of topiramate and amitriptyline either alone or in combination for the prevention of migraine.
Effectiveness of antidepressants and antiepileptic drugs has already been demonstrated for migraine prophylaxis as monotherapy. In the present study, the efficacy and tolerability of amitriptyline and topiramate combination is examined in the prevention of migraine attacks, in comparison to the monotherapy of each drug. ⋯ Amitriptyline and topiramate combination may be beneficial for patients with migraine and comorbid depression, particularly in terms of side effects and associated displeasure due to monotherapy.