Clinical neurology and neurosurgery
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Clin Neurol Neurosurg · Jan 2009
Review Case ReportsLeber's optic neuropathy associated with disseminated white matter disease: a case report and review.
Leber's hereditary optic neuropathy (LHON), a mitochondrial disease, is clinically characterized by a bilateral subacute loss of central vision consecutive to optic nerve involvement. In some cases of LHON, neurological features are reported including multiple sclerosis-like (MSL) phenotype. ⋯ We discuss the respective roles of inflammation and energetic metabolism dysregulation in the development of brain lesions. We propose to treat these patients early with both antioxidative and immunosuppressive drugs in order to avoid further handicap.