Clinical neurology and neurosurgery
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Clin Neurol Neurosurg · Jul 2012
ReviewIntrathecal granuloma formation as result of opioid delivery: systematic literature review of case reports and analysis against a control group.
To investigate the existence of an association between formation of catheter tip intrathecal inflammatory masses with opioid dose and/or concentration. ⋯ Opioid dose and concentration were significantly associated with the development of catheter tip granulomas. A correlation with opioid concentration was confirmed for the first time.