Clinical neurology and neurosurgery
-
Clin Neurol Neurosurg · Oct 2013
Randomized Controlled TrialEffect of progesterone administration on prognosis of patients with diffuse axonal injury due to severe head trauma.
Severe traumatic brain injury (TBI) has a major role in mortality rate among the other types of trauma. The aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with acute severe TBI. ⋯ The use of progesterone may significantly improve neurologic outcome of patients suffering severe TBI up to 3 months after injury, especially those with 5≤GCS≤8, providing a potential benefit to the treatment of acute severe TBI patients. Considering this drug had no significant side effects, so progesterone could be used in patients with severe TBI as a neuro-protective drug.