The Journal of family practice
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Randomized Controlled Trial
Is low-dose naltrexone effective in chronic pain management?
YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).
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Many students want to skip school from time to time. But when absenteeism becomes chronic, it may indicate a more serious underlying issue.
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These agents are as effective as traditional acute and preventive treatments, cause fewer adverse effects, and can simplify regimens.
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The evidence supports patient use of this simple equation to evaluate the nutrition labels of packaged carbohydrate foods in the grocery aisle in order to make healthier decisions.