The Journal of the American Dental Association
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Randomized Controlled Trial Comparative Study
Flumazenil reversal of sublingual triazolam: a randomized controlled clinical trial.
Incremental sublingual (SL) dosing of triazolam has emerged as a popular sedation technique. Nevertheless, few studies have evaluated the technique's safety or efficacy. Given its popularity, an easily administered rescue strategy is needed. ⋯ A single intraoral injection of flumazenil (0.2 mg) cannot immediately reverse oversedation with triazolam. A higher dose might be effective. Reversal for the purpose of discharging the patient early is neither appropriate nor safe.