The Journal of the American Dental Association
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Review Meta Analysis
Phentolamine mesylate to reverse oral soft-tissue local anesthesia: A systematic review and meta-analysis.
Knowing that patients desire reduced duration of local anesthesia, the authors performed a meta-analysis to evaluate the efficacy of phentolamine mesylate (PM) in reducing anesthesia duration and the occurrence of adverse effects. ⋯ Based on limited evidence, PM is effective in reducing the persistence of anesthesia duration on the lower lip and tongue, with infrequent adverse effects of little clinical significance.