Journal of the American Geriatrics Society
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Randomized Controlled Trial Multicenter Study
Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture.
To assess the association between serum S100B levels (a marker of brain damage), delirium, and subsequent cognitive decline. ⋯ In a cohort of older adults with hip fracture, no association was found between serum S100B levels and occurrence of delirium. S100B was associated with cognitive decline or death in the first year after hip fracture only in participants without perioperative delirium. S100B seems to be of limited value as a biomarker of brain damage associated with delirium.