Journal of the American Geriatrics Society
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Meta Analysis
Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis.
To assess and quantify the risk of drug-induced dry mouth as a side effect in older people. ⋯ Medication use was significantly associated with xerostomia and salivary gland hypofunction in older adults. The risk of dry mouth was greatest for drugs used for urinary incontinence. Future research should develop a risk score for medication-induced dry mouth to assist with prescribing and medication management.
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To examine the comparative effectiveness and safety of cognitive enhancers for Alzheimer's disease (AD). ⋯ An exhaustive review of the literature involving 142 studies demonstrated that cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice.