Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jan 2009
Randomized Controlled TrialVitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial.
Observational studies suggested that a diet high in fruits and vegetables, both of which are rich with antioxidants, may prevent cancer development. However, findings from randomized trials of the association between antioxidant use and cancer risk have been mostly negative. ⋯ Supplementation with vitamin C, vitamin E, or beta carotene offers no overall benefits in the primary prevention of total cancer incidence or cancer mortality.