Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Oct 2011
Randomized Controlled Trial Multicenter StudySequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410.
The combination of chemotherapy with thoracic radiotherapy (TRT) compared with TRT alone has been shown to confer a survival advantage for good performance status patients with stage III non-small cell lung cancer. However, it is not known whether sequential or concurrent delivery of these therapies is the optimal combination strategy. ⋯ Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies.
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J. Natl. Cancer Inst. · Oct 2011
Randomized Controlled Trial Comparative StudyProof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine.
Three-dose regimens for human papillomavirus (HPV) vaccines are expensive and difficult to complete, especially in settings where the need for cervical cancer prevention is greatest. ⋯ Four years after vaccination of women who appeared to be uninfected, this nonrandomized analysis suggests that two doses of the HPV16/18 vaccine, and maybe even one dose, are as protective as three doses.