Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Sep 2012
Review Meta AnalysisNeurokinin-1 receptor antagonists for chemotherapy-induced nausea and vomiting: a systematic review.
The addition of neurokinin-1 receptor (NK1R) antagonists to antiemetic regimens has substantially reduced chemotherapy-induced nausea and vomiting (CINV). We sought to systematically review the overall impact of NK1R antagonists on CINV prevention. ⋯ NK1R antagonists increased CINV control in the acute, delayed, and overall phases. They are effective for both moderately and highly emetogenic chemotherapy regimens. Their use might be associated with increased infection rates; however, additional appraisal of specific data from RCTs is needed.