British journal of clinical pharmacology
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Br J Clin Pharmacol · Aug 1997
Clinical Trial Controlled Clinical TrialThe pharmacokinetics and pharmacodynamics of rocuronium in patients with hepatic cirrhosis.
To determine the effects of hepatic cirrhosis on the pharmacodynamics and pharmacokinetics of rocuronium bromide. ⋯ Hepatic elimination is an important pathway in the clearance of rocuronium, and delayed disposition causes the effect to be prolonged.
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Br J Clin Pharmacol · Aug 1997
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of the effects of aspirin on bleeding time measured using the Simplate method and closure time measured using the PFA-100, in healthy volunteers.
The aim of this study was to compare the effects of aspirin on platelet function as measured by the 'classical' template bleeding time with a new ex vivo method measuring closure times using the PFA-100 machine. Platelet aggregation in response to arachidonic acid was also measured ex vivo. ⋯ The change in closure time using the PFA-100 is as sensitive and reproducible to the effects of aspirin on platelet function as is the template bleeding time test. However, the PFA-100 produced less variable effects with fewer false positive results.
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Case-reports describing patients who developed a first episode of acute gout while being treated with the proton pump inhibitor omeprazole led us to compare incidence rates of newly diagnosed gout cases among omeprazole, ranitidine and cimetidine users. ⋯ While other known risk factors were significantly associated with gout, current omeprazole use was not materially associated with an increased gout incidence.