British journal of clinical pharmacology
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Br J Clin Pharmacol · May 1998
Clinical TrialDistribution and excretion of venlafaxine and O-desmethylvenlafaxine in human milk.
To characterise the transfer of venlafaxine (V) and its O-desmethyl metabolite (ODV) into human milk by measuring milk/plasma (M/P) ratio, and to estimate the likely dose received by a breast-fed infant. ⋯ These preliminary data show that the total dose of V and ODV ingested by breast-fed infants can be as high as 9.2% of maternal intake. Moreover there were measurable concentrations of ODV in the infants' plasma. We recommend that exposed infants should be observed closely.