British journal of clinical pharmacology
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Br J Clin Pharmacol · Nov 1999
Randomized Controlled Trial Clinical TrialImpact of gastric emptying on the pharmacokinetics of ethanol as influenced by cisapride.
To examine the influence of cisapride on the pharmacokinetics of ethanol and the impact of gastric emptying monitored by the paracetamol absorption test. ⋯ A small but statistically significant increase in Cmax occurred after treatment with cisapride owing to faster gastric emptying rate as shown by the paracetamol absorption test. However, the rate of absorption of ethanol, as reflected in Cmax and AUC, was greatest after drinking the alcohol on an empty stomach. The cisapride-ethanol interaction probably lacks any clinical or forensic significance.