British journal of clinical pharmacology
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Br J Clin Pharmacol · Aug 2004
Meta AnalysisPopulation pharmacokinetics of APOMINE: a meta-analysis in cancer patients and healthy males.
1) To characterize the population pharmacokinetics of apomine in healthy males and in male and female patients with solid tumours and 2) to understand more fully the influence of induction and between- and within-subject variability on exposure to drug using Monte Carlo simulation. ⋯ A population model for apomine has been developed has been developed that characterizes its pharmacokinetics in cancer patients and healthy subjects under a variety of conditions.