British journal of clinical pharmacology
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Br J Clin Pharmacol · Sep 2004
Randomized Controlled Trial Clinical TrialCan coadministration of oxycodone and morphine produce analgesic synergy in humans? An experimental cold pain study.
The coadministration of subantinociceptive doses of oxycodone with morphine has recently been shown to result in a synergistic antinociceptive effect in rats. The present study was aimed to investigate the possibility that coadministration of morphine and oxycodone can produce a similar synergistic effect in humans exposed to an experimental model of cold pressor test (CPT). ⋯ These results indicate that at the doses tested, morphine and oxycodone do not produce synergistic antinociceptive effects in healthy humans exposed to the CPT.