British journal of clinical pharmacology
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Br J Clin Pharmacol · Dec 2007
Randomized Controlled Trial Comparative StudyEffect of dronedarone on renal function in healthy subjects.
To assess the effects of dronedarone on renal function and tubular cation handling. ⋯ Dronedarone reduces renal creatinine and NMN clearance by about 18%, without evidence of an effect on GFR, renal plasma flow or electrolyte exchanges. This suggests a specific partial inhibition of tubular organic cation transporters (OCT). A limited increase in serum creatinine is therefore expected with dronedarone treatment, but does not mean there is a decline in renal function.