British journal of clinical pharmacology
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Br J Clin Pharmacol · Aug 2008
Randomized Controlled TrialDose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk.
To investigate the possibility of a dose-response relationship for the use of domperidone in treating insufficient milk supply in mothers of preterm infants, and to quantify the exposure of the breastfed infant to domperidone. ⋯ In one-third of mothers, domperidone did not increase milk production. In the remainder, milk production increased at both domperidone doses, and there was a trend for a dose-response relationship. The amount of domperidone that transfers into milk was extremely low, and infant exposure via breastfeeding was not considered to be significant.